Article
A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.
Molecular cancer - 4 Aug 2014
Rosemann Michael, Gonzalez-Vasconcellos Iria, Domke Tanja, Kuosaite Virginija, Schneider Ralf, Kremer Markus, Favor Jack, Nathrath Michaela, Atkinson Michael J
Abstract excerpt
BACKGROUND: Syndromic forms of osteosarcoma (OS) account for less than 10% of all recorded cases of this malignancy. An individual OS predisposition is also possible by the inheritance of low penetrance alleles of tumor susceptibility genes, usually without evidence of a syndromic condition. Genetic variants involved in such a non-syndromic form of tumor predisposition are difficult to identify, given the low...
Topics
- 3' Untranslated Regions
- Allelic Imbalance
- Animals
- Base Sequence
- Binding Sites
- Carcinogenesis
- Cell Line, Tumor
- Chromosomes, Mammalian
- Crosses, Genetic
- Female