Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of genes of the Rb1 signalling pathway on osteosarcoma incidence and latency in alpha-particle irradiated mice.

Radiation and environmental biophysics - 1 Mar 2011

Gonzalez-Vasconcellos Iria, Domke Tanja, Kuosaite Virginija, Esposito Irene, Sanli-Bonazzi Bahar, Nathrath Michaela, Atkinson Michael J, Rosemann Michael

Abstract excerpt

Osteosarcoma is the most frequent secondary malignancy following radiotherapy of patients with bilateral retinoblastoma. This suggests that the Rb1 tumour suppressor gene might confer genetic susceptibility towards radiation-induced osteosarcoma. To define the contribution of the Rb1 pathway in the multistep process of radiation carcinogenesis, we evaluated somatic allelic changes affecting the Rb1 gene itself as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allelic Imbalance
Share to Alpha Particles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bone and Bones

Share to Bone Neoplasms

Share to Genes, p16

Share to Neoplasms, Radiation-Induced

Share to Osteosarcoma

Share to Retinoblastoma Protein

Source

Identifiers

PMID: 21063720
DOI: 10.1007/s00411-010-0339-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effects of genes of the Rb1 signalling pathway on osteosarcoma incidence and latency in alpha-particle irradiated mice.PMID 21063720Read ↗

A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.Semantic proximity Read ↗

Rb1 haploinsufficiency promotes telomere attrition and radiation-induced genomic instability.Semantic proximity Read ↗

Multilocus inheritance determines predisposition to alpha-radiation induced bone tumourigenesis in mice.Semantic proximity Read ↗

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.Semantic proximity Read ↗

RB1 and TP53 pathways in radiation-induced sarcomasSemantic proximity Read ↗

A susceptibility locus for radiation lymphomagenesis on mouse chromosome 16.Semantic proximity Read ↗

Osteosarcoma without prior retinoblastoma related to RB1 low‐penetrance germline pathogenic variants: A novel type of RB1‐related hereditary predisposition syndrome?Semantic proximity Read ↗

Correlation between RB1germline mutations and second primary malignancies in hereditary retinoblastoma patients treated with external beam radiotherapySemantic proximity Read ↗

Osteosarcomagenesis: Modeling Cancer Initiation in the MouseSemantic proximity Read ↗

The genetics of radiation-induced and sporadic osteosarcoma: a unifying theory?Semantic proximity Read ↗

Osteosarcoma following retinoblastoma: age at onset and latency period.Semantic proximity Read ↗

Mesenchymal stromal cells having inactivated RB1 survive following low irradiation and accumulate damaged DNA: Hints for side effects following radiotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.