Multilocus inheritance determines predisposition to alpha-radiation induced bone tumourigenesis in mice.

doi:10.1002/ijc.21612

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Article

Multilocus inheritance determines predisposition to alpha-radiation induced bone tumourigenesis in mice.

International journal of cancer - 1 May 2006

Rosemann Michael, Kuosaite Virginija, Kremer Markus, Favor Jack, Quintanilla-Martinez Leticia, Atkinson Michael J

Abstract excerpt

In a recent study, we presented evidence for genetic predisposition governing radiation osteosarcomagenesis in mice. Following the incorporation of the bone-seeking alpha emitter 227Th, approximately 25% of the variance in osteosarcoma incidence was determined by inherited genetic factors. We have now mapped 5 susceptibility loci in crosses between the more susceptible BALB/c and the more resistant CBA/Ca...

Topics

Alpha Particles
Animals
Bone Neoplasms
Chromosome Mapping
Female
Genetic Predisposition to Disease
Genotype
Humans
Inheritance Patterns
Male
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Osteosarcoma
Phenotype
Quantitative Trait Loci
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 16331598
DOI: 10.1002/ijc.21612

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