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Article

Integrated genomics of susceptibility to alkylator-induced leukemia in mice.

BMC genomics - 17 Nov 2010

Cahan Patrick, Graubert Timothy A

Abstract excerpt

BACKGROUND: Therapy-related acute myeloid leukemia (t-AML) is a secondary, generally incurable, malignancy attributable to chemotherapy exposure. Although there is a genetic component to t-AML susceptibility in mice, the relevant loci and the mechanism(s) by which they contribute to t-AML are largely unknown. An improved understanding of susceptibility factors and the biological processes in which they act may...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21080971
DOI: 10.1186/1471-2164-11-638
PMCID: PMC3018144

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Source receipt: pubmed, retrieved 7 Sept 2026.

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