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Article

Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.

Carcinogenesis - 1 Feb 2006

Darakhshan F, Badie C, Moody J, Coster M, Finnon R, Finnon P, Edwards A A, Szluinska M, Skidmore C J, Yoshida K, Ullrich R, Cox R, Bouffler S D

Abstract excerpt

The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute myeloid leukaemia (AML) in the mouse based on chromosomal radiosensitivity has been developed and validated. This assay was applied to the mapping of radiation-induced AML risk modifier loci by association with microsatellite markers. A region on chromosome...

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PMID: 16093251
DOI: 10.1093/carcin/bgi207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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