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Article

Osteosarcomagenesis: Modeling Cancer Initiation in the Mouse

1 Jan 2011

Abstract excerpt

Osteosarcoma remains a deadly malignancy afflicting adolescents and young adults. The lack of a precursor and the panoply of genetic aberrations present in identified osteosarcomas makes study of its initiation difficult. A number of candidate hypotheses have been tested in the mouse, a species with a higher background incidence of osteosarcoma. Chemical carcinogens, external beam radiation, and bone-seeking...

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PMID: 21403899
DOI: 10.1155/2011/694136

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