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Article

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer.

Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2011

Tili Esmerina, Michaille Jean-Jacques, Wernicke Dorothee, Alder Hansjuerg, Costinean Stefan, Volinia Stefano, Croce Carlo M

Abstract excerpt

Infection-driven inflammation has been implicated in the pathogenesis of ~15-20% of human tumors. Expression of microRNA-155 (miR-155) is elevated during innate immune response and autoimmune disorders as well as in various malignancies. However, the molecular mechanisms providing miR-155 with its oncogenic properties remain unclear. We examined the effects of miR-155 overexpression and proinflammatory...

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Identifiers

PMID: 21383199
DOI: 10.1073/pnas.1101795108
PMCID: PMC3064319

Genes

WEE1

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