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Article

Promoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence.

Journal of experimental & clinical cancer research : CR - 5 Aug 2014

Rengucci Claudia, De Maio Giulia, Casadei Gardini Andrea, Zucca Mattia, Scarpi Emanuela, Zingaretti Chiara, Foschi Giovanni, Tumedei Maria Maddalena, Molinari Chiara, Saragoni Luca, Puccetti Maurizio, Amadori Dino, Zoli Wainer, Calistri Daniele

Abstract excerpt

BACKGROUND: Epigenetic alterations of specific genes have been reported to be related to colorectal cancer (CRC) transformation and would also appear to be involved in the early stages of colorectal carcinogenesis. Little data are available on the role of these alterations in determining a different risk of colorectal lesion recurrence. The aim of the present study was to verify whether epigenetic alterations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25091577
DOI: 10.1186/s13046-014-0065-x
PMCID: PMC4274757

Genes

FHIT
MLH1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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