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Identification of Predictive DNA Methylation Biomarkers for Chemotherapy Response in Colorectal Cancer

12 Feb 2017

Abstract excerpt

Resistance to 5-Fluorouracil (5-FU) is a major obstacle to the successful treatment of colorectal cancer (CRC) and posed an increased risk of recurrence. DNA methylation has been suggested as one of the underlying mechanisms for recurrent disease and its contribution to the development of drug resistance remains to be clarified. This study aimed to determine the methylation phenotype in CRC for identification of...

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PMID: 28243201
DOI: 10.3389/fphar.2017.00047

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