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Article

Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.

Biochemical and biophysical research communications - 22 Aug 2014

Du Chenchen, Jin Mengmeng, Hong Yu, Li Qian, Wang Xian-Hui, Xu Jin-Min, Wang Fen, Zhang Ye, Jia Jia, Liu Chun-Feng, Hu Li-Fang

Abstract excerpt

Microglia-mediated neuroinflammation is implicated in the pathogenesis of several neurodegenerative disorders. Microglia can be activated and polarized to exert pro- or anti-inflammatory roles in response to specific stimulus. Rotenone is an environmental toxin that has been shown to activate microglia and neuroinflammation. However, the effects and mechanisms of rotenone on microglia polarization are poorly...

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PMID: 25086357
DOI: 10.1016/j.bbrc.2014.07.107

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CBS
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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