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Article

Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts.

Molecular pharmacology - 1 Oct 2014

Raveh Avi, Schultz Pamela J, Aschermann Lauren, Carpenter Colleen, Tamayo-Castillo Giselle, Cao Shugeng, Clardy Jon, Neubig Richard R, Sherman David H, Sjögren Benita

Abstract excerpt

Biochemical high-throughput screening is widely used in drug discovery, using a variety of small molecule libraries. However, broader screening strategies may be more beneficial to identify novel biologic mechanisms. In the current study we used a β-galactosidase complementation method to screen a selection of microbial-derived pre-fractionated natural product extracts for those that increase regulator of G...

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Source

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Identifiers

PMID: 25086086
DOI: 10.1124/mol.114.092403
PMCID: PMC6067637

Genes

RGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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