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Design of phenotypic screens for bioactive chemicals and identification of their targets by genetic and proteomic approaches.

Combinatorial chemistry & high throughput screening - 1 Sept 2008

Schriemer David C, Kemmer Danielle, Roberge Michel

Abstract excerpt

Cell-based screening using phenotypic assays is a useful means of identifying bioactive chemicals for use as tools to elucidate complex cellular processes. However, the chemicals must display sufficient selectivity and their targets have to be identified. We describe how cell-based screening assays can be designed to maximize the likelihood of discovering selective compounds through the choice of positive...

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PMID: 18795880
DOI: 10.2174/138620708785739934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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