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Article

Does estrogen deficiency cause lacrimal gland inflammation and aqueous-deficient dry eye in mice?

Experimental eye research - 1 Oct 2014

Rahimi Darabad Raheleh, Suzuki Tomo, Richards Stephen M, Jakobiec Frederick A, Zakka Fouad R, Barabino Stefano, Sullivan David A

Abstract excerpt

Researchers have proposed that estrogen deficiency will lead to a Sjögren's syndrome (SjS)-like lacrimal gland inflammation, aqueous tear deficiency and dry eye. The purpose of this study was to determine whether this proposal is correct. Lacrimal glands were obtained from adult, age-matched wild type (WT) and aromatase knockout (ArKO) mice, in which estrogen synthesis is completely eliminated. Tissues were also...

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Identifiers

PMID: 25084452
DOI: 10.1016/j.exer.2014.07.017
PMCID: PMC4175142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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