Article
Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages.
The American journal of pathology - 1 Jan 2015
Iwasa Akihiko, Arakaki Rieko, Honma Naoko, Ushio Aya, Yamada Akiko, Kondo Tomoyuki, Kurosawa Emi, Kujiraoka Satoko, Tsunematsu Takaaki, Kudo Yasusei, Tanaka Eiji, Yoshimura Noriko, Harada Nobuhiro, Hayashi Yoshio, Ishimaru Naozumi
Abstract excerpt
Several autoimmune diseases are known to develop in postmenopausal women. However, the mechanism by which estrogen deficiency influences autoimmunity is unknown. Aromatase is an enzyme that converts androgens to estrogens. Herein, we used female aromatase gene knockout (ArKO) mice as a model of estrogen deficiency to investigate the molecular mechanism that underlies the onset and development of autoimmunity....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.