Article
Ocular surface disease and dacryoadenitis in aging C57BL/6 mice.
The American journal of pathology - 1 Mar 2014
McClellan Andrew J, Volpe Eugene A, Zhang Xiaobo, Darlington Gretchen J, Li De-Quan, Pflugfelder Stephen C, de Paiva Cintia S
Abstract excerpt
Dry eye in humans displays increased prevalence in the aged and in women. Here, we investigated the ocular surfaces and lacrimal glands of aged mice of both sexes. We surveyed three different ages [young, middle-aged (6 to 9 months), and elderly] by investigating severity markers of dry eye disease (DED). We observed an age-dependent dry eye phenotype as early as 6 to 9 months: increased corneal surface...
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