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Article

Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye.

The American journal of pathology - 1 Sept 2012

Zhou Delu, Chen Ying-Ting, Chen Feeling, Gallup Marianne, Vijmasi Trinka, Bahrami Ahmad F, Noble Lisa B, van Rooijen Nico, McNamara Nancy A

Abstract excerpt

Lymphocytic infiltration of the lacrimal gland and ocular surface in autoimmune diseases such as Sjögren's syndrome (SS) causes an aqueous-deficient dry eye that is associated with significant morbidity. Previous studies from our laboratory and others have established autoimmune regulator (Aire)-deficient mice as a useful model to examine exocrinopathy and ocular surface disease associated with SS. Consistent...

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Identifiers

PMID: 22770665
DOI: 10.1016/j.ajpath.2012.05.014
PMCID: PMC3432423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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