Article
Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren's syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2004
Shim Gil-Jin, Warner Margaret, Kim Hyun-Jin, Andersson Sandra, Liu Lining, Ekman Jenny, Imamov Otabek, Jones Margaret E, Simpson Evan R, Gustafsson Jan-Ake
Abstract excerpt
Sjögren's syndrome (SS) is an incurable, autoimmune exocrinopathy that predominantly affects females and whose pathogenesis remains unknown. Like rheumatoid arthritis, its severity increases after menopause, and estrogen deficiency has been implicated. We have reported that estrogen receptor-alpha and -beta-knockout mice develop autoimmune nephritis and myeloid leukemia, respectively, but neither develops SS. One...
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