Article
Influence of aromatase absence on the gene expression and histology of the mouse meibomian gland.
Investigative ophthalmology & visual science - 5 Feb 2013
Darabad Raheleh Rahimi, Suzuki Tomo, Richards Stephen M, Jensen Roderick V, Jakobiec Frederick A, Zakka Fouad R, Liu Shaohui, Sullivan David A
Abstract excerpt
PURPOSE: We hypothesize that aromatase, an enzyme that controls estrogen biosynthesis, plays a major role in the sex-related differences of the meibomian gland. To begin to test this hypothesis, we examined the influence of aromatase absence, which completely eliminates estrogen production, on glandular gene expression and histology in male and female mice. METHODS: Meibomian glands were obtained from adult,...
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