Article

Spatial transcriptomic profiling identifies lacrimal gland epithelial cell-driven mechanisms underlying autoimmunity in Sjögren’s disease

2025-11-05

Abstract excerpt

Sjögren’s disease (SjD) is a second most prevalent rheumatic disease involving autoimmune pathology of tear-producing lacrimal glands that leads to a common clinical manifestation of chronic ocular surface disease. Despite advances in understanding of SjD, lacrimal gland pathology remains incompletely understood limiting diagnosis and treatment. Here we analyze spatial transcriptomic profile of lacrimal glands fro...

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Literature Corpus work: 8c467e15-cd13-504a-b96c-29b51a1ba657
DOI: 10.1101/2025.11.03.686353

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