Article
Time course of cytokine upregulation in the lacrimal gland and presence of autoantibodies in a predisposed mouse model of Sjögren's Syndrome: the influence of sex hormones and genetic background.
Experimental eye research - 1 Nov 2014
Czerwinski Stefanie, Mostafa Safinaz, Rowan Vanessa Seamon, Azzarolo Ana Maria
Abstract excerpt
Sjögren's Syndrome (SS) is a chronic, inflammatory autoimmune disease characterized by lacrimal gland lymphocytic infiltration and epithelial cell death, as well as by the presence of serum autoantibodies. Although the symptoms of this syndrome are well characterized, patients are not diagnosed until 5-10 years into disease progression; furthermore, the early series of events leading to the initiation of SS are...
Topics
- Animals
- Antibodies, Antinuclear
- Autoantibodies
- Cytokines
- Dihydrotestosterone
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Estradiol
- Female
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Lacrimal Apparatus