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Article

Polymorphisms of the vincristine pathway and response to treatment in children with childhood acute lymphoblastic leukemia.

Pharmacogenomics - 1 Jun 2014

Ceppi Francesco, Langlois-Pelletier Chloé, Gagné Vincent, Rousseau Julie, Ciolino Claire, De Lorenzo Samanta, Kevin Kojok M, Cijov Diana, Sallan Stephen E, Silverman Lewis B, Neuberg Donna, Kutok Jeffery L, Sinnett Daniel, Laverdière Caroline, Krajinovic Maja

Abstract excerpt

BACKGROUND: Vincristine (VCR) is a standard component in the treatment of childhood acute lymphoblastic leukemia (ALL). VCR cytotoxicity is primarily due to its ability to disrupt the formation of microtubules of the mitotic spindle. PATIENTS & METHODS: Seventeen polymorphisms in regulatory and coding regions of genes controlling VCR targets (TUBB1, MAP4, ACTG1 and CAPG) or potentially influencing VCR levels...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25084203
DOI: 10.2217/pgs.14.68
PMCID: PMC4443746

Genes

ABCB1
ACTG1
CAPG
MAP4
TUBB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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