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Vincristine pharmacokinetics pathway and neurotoxicity during early phases of treatment in pediatric acute lymphoblastic leukemia.

Pharmacogenomics - 1 May 2016

Lopez-Lopez Elixabet, Gutierrez-Camino Angela, Astigarraga Itziar, Navajas Aurora, Echebarria-Barona Aizpea, Garcia-Miguel Purificacion, Garcia de Andoin Nagore, Lobo Carmen, Guerra-Merino Isabel, Martin-Guerrero Idoia, Garcia-Orad Africa

Abstract excerpt

AIM: Vincristine is an important component of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from vincristine-related neurotoxicity in early phases of treatment. Recently, a genome-wide association study connected a SNP in CEP72, involved in vincristine pharmacodynamics, with neurotoxicity during later phases of therapy,...

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Source

Identifiers

PMID: 27180762
DOI: 10.2217/pgs-2016-0001

Genes

ABCC2
CEP72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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