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Article

Mir-pharmacogenetics of Vincristine and peripheral neurotoxicity in childhood B-cell acute lymphoblastic leukemia.

The pharmacogenomics journal - 1 Dec 2018

Gutierrez-Camino Ángela, Umerez Maitane, Martin-Guerrero Idoia, García de Andoin Nagore, Santos Borja, Sastre Ana, Echebarria-Barona Aizpea, Astigarraga Itziar, Navajas Aurora, Garcia-Orad Africa

Abstract excerpt

Vincristine (VCR), an important component of childhood acute lymphoblastic leukemia (ALL) therapy, can cause sensory and motor neurotoxicity. This neurotoxicity could lead to dose reduction or treatment discontinuation, which could in turn reduce survival. In this line, several studies associated peripheral neurotoxicity and polymorphisms in genes involved in pharmacokinetics (PK) and pharmacodynamics (PD) of...

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Identifiers

PMID: 29282364
DOI: 10.1038/s41397-017-0003-3

Genes

ABCC1
MAF
RALBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Mir-pharmacogenetics of Vincristine and peripheral neurotoxicity in childhood B-cell acute lymphoblastic leukemia.PMID 29282364Read ↗

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Genetic Variants Associated With Vincristine‐Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Genetic Polymorphisms Associated with Vincristine Pharmacokinetics and Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology PatientsSemantic proximity Read ↗

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Pharmacogenomics of Vincristine‐Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy GenesSemantic proximity Read ↗

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