Article
CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer.
Pediatric blood & cancer - 1 Mar 2018
Skiles Jodi L, Chiang ChienWei, Li Claire H, Martin Steve, Smith Ellen L, Olbara Gilbert, Jones David R, Vik Terry A, Mostert Saskia, Abbink Floor, Kaspers Gertjan J, Li Lang, Njuguna Festus, Sajdyk Tammy J, Renbarger Jamie L
Abstract excerpt
BACKGROUND: Vincristine (VCR) is a critical part of treatment in pediatric malignancies and is associated with dose-dependent peripheral neuropathy (vincristine-induced peripheral neuropathy [VIPN]). Our previous findings show VCR metabolism is regulated by the CYP3A5 gene. Individuals who are low CYP3A5 expressers metabolize VCR slower and experience more severe VIPN as compared to high expressers. Preliminary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.