Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.

doi:10.1001/jama.2015.0894

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Article

Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.

JAMA - 24 Feb 2015

Diouf Barthelemy, Crews Kristine R, Lew Glen, Pei Deqing, Cheng Cheng, Bao Ju, Zheng Jie J, Yang Wenjian, Fan Yiping, Wheeler Heather E, Wing Claudia, Delaney Shannon M, Komatsu Masaaki, Paugh Steven W, McCorkle Joseph Robert, Lu Xiaomin, Winick Naomi J, Carroll William L, Loh Mignon L, Hunger Stephen P, Devidas Meenakshi, Pui Ching-Hon, Dolan M Eileen, Relling Mary V, Evans William E

Abstract excerpt

IMPORTANCE: With cure rates of childhood acute lymphoblastic leukemia (ALL) exceeding 85%, there is a need to mitigate treatment toxicities that can compromise quality of life, including peripheral neuropathy from vincristine treatment. OBJECTIVE: To identify genetic germline variants associated with the occurrence or severity of vincristine-induced peripheral neuropathy in children with ALL. DESIGN, SETTING, AND...

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Identifiers

PMID: 25710658
DOI: 10.1001/jama.2015.0894
PMCID: PMC4377066

Genes

CEP72

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Source receipt: pubmed, retrieved 6 Sept 2026.

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