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Article

Precision Medicine in Childhood Cancer: The Influence of Genetic Polymorphisms on Vincristine-Induced Peripheral Neuropathy.

International journal of molecular sciences - 13 Aug 2024

Marangoni-Iglecias Luciana, Rojo-Tolosa Susana, Márquez-Pete Noelia, Cura Yasmín, Moreno-Toro Noelia, Membrive-Jiménez Cristina, Sánchez-Martin Almudena, Pérez-Ramírez Cristina, Jiménez-Morales Alberto

Abstract excerpt

Cancer is the leading cause of disease-related death among children. Vincristine (VCR), a key component of childhood cancer treatment protocols, is associated with the risk of peripheral neuropathy (PN), a condition that may be reversible upon drug discontinuation but can also leave lasting sequelae. Single nucleotide polymorphism (SNP) in genes involved in VCR pharmacokinetics and pharmacodynamics have been...

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Identifiers

PMID: 39201483
DOI: 10.3390/ijms25168797
PMCID: PMC11354794

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Precision Medicine in Childhood Cancer: The Influence of Genetic Polymorphisms on Vincristine-Induced Peripheral Neuropathy.PMID 39201483Read ↗

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