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Article

Genetic risk factors for VIPN in childhood acute lymphoblastic leukemia patients identified using whole-exome sequencing.

Pharmacogenomics - 1 Oct 2018

Abaji Rachid, Ceppi Francesco, Patel Swati, Gagné Vincent, Xu Chang J, Spinella Jean-François, Colombini Antonella, Parasole Rosanna, Buldini Barbara, Basso Giuseppe, Conter Valentino, Cazzaniga Giovanni, Leclerc Jean-Marie, Laverdière Caroline, Sinnett Daniel, Krajinovic Maja

Abstract excerpt

AIM: To identify genetic markers associated with vincristine-induced peripheral neuropathy (VIPN) in childhood acute lymphoblastic leukemia. PATIENTS & METHODS: Whole-exome sequencing data were combined with exome-wide association study to identify predicted-functional germline variants associated with high-grade VIPN. Genotyping was then performed for top-ranked signals (n = 237), followed by validation in...

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Identifiers

PMID: 30191766
DOI: 10.2217/pgs-2018-0093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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