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Article

Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia.

Pediatric blood & cancer - 1 Mar 2011

Egbelakin Akinbode, Ferguson Michael J, MacGill Emily A, Lehmann Amalia S, Topletz Ariel R, Quinney Sara K, Li Lang, McCammack Kevin C, Hall Stephen D, Renbarger Jamie L

Abstract excerpt

BACKGROUND: This study evaluates the relationship between cytochrome P450 (CYP) 3A5 genotype and vincristine-induced peripheral neuropathy (VIPN) in children with precursor B cell acute lymphoblastic leukemia (preB ALL). We have shown in vitro that vincristine is metabolized significantly more efficiently by CYP3A5 than by CYP3A4. We also found that vincristine neurotoxicity is less common in African-Americans...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21225912
DOI: 10.1002/pbc.22845
PMCID: PMC3020258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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