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Abnormal Motor Phenotype at Adult Stages in Mice Lacking Type 2 Deiodinase

1 Aug 2014

Abstract excerpt

BACKGROUND: Thyroid hormones have a key role in both the developing and adult central nervous system and skeletal muscle. The thyroid gland produces mainly thyroxine (T4) but the intracellular concentrations of 3,5,3'-triiodothyronine (T3; the transcriptionally active hormone) in the central nervous system and skeletal muscle are modulated by the activity of type 2 deiodinase (D2). To date no neurological...

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PMID: 25083788
DOI: 10.1371/journal.pone.0103857

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