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Article

Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.

Thyroid : official journal of the American Thyroid Association - 1 Apr 2017

Ignacio Daniele L, Silvestre Diego H S, Anne-Palmer Elena, Bocco Barbara M L C, Fonseca Tatiana L, Ribeiro Miriam O, Gereben Balázs, Bianco Antonio C, Werneck-de-Castro Joao P

Abstract excerpt

BACKGROUND: Myogenesis is positively regulated by thyroid hormone (triiodothyronine [T3]), which is amplified by the type 2 deiodinase (D2) activation of thyroxine to T3. Global inactivation of the Dio2 gene impairs skeletal muscle (SKM) differentiation and regeneration in response to muscle injury. Given that newborn and adult mice with late developmental SKM Dio2 disruption do not develop a significant...

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Identifiers

PMID: 27967605
DOI: 10.1089/thy.2016.0392
PMCID: PMC5385430

Genes

MYF5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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