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Article

Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2004

Ng Lily, Goodyear Richard J, Woods Chad A, Schneider Mark J, Diamond Edward, Richardson Guy P, Kelley Matthew W, Germain Donald L St, Galton Valerie Anne, Forrest Douglas

Abstract excerpt

The later stages of cochlear differentiation and the developmental onset of hearing require thyroid hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely that other factors modify TR activity during cochlear development. The mouse cochlea expresses type 2 deiodinase (D2), an enzyme that converts thyroxine, the main form of thyroid hormone in the circulation, into...

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Share to Cochlea
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Thyroid Hormone

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Source

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Identifiers

PMID: 14993610
DOI: 10.1073/pnas.0307402101
PMCID: PMC373486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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