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Article

Type 3 deiodinase is critical for the maturation and function of the thyroid axis.

The Journal of clinical investigation - 1 Feb 2006

Hernandez Arturo, Martinez M Elena, Fiering Steven, Galton Valerie Anne, St Germain Donald

Abstract excerpt

Developmental exposure to appropriate levels of thyroid hormones (THs) in a timely manner is critical to normal development in vertebrates. Among the factors potentially affecting perinatal exposure of tissues to THs is type 3 deiodinase (D3). This enzyme degrades THs and is highly expressed in the pregnant uterus, placenta, and fetal and neonatal tissues. To determine the physiological role of D3, we have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16410833
DOI: 10.1172/JCI26240
PMCID: PMC1326144

Genes

TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Type 3 deiodinase is critical for the maturation and function of the thyroid axis.PMID 16410833Read ↗

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