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Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia

21 Nov 2019

Abstract excerpt

Hematopoiesis, the formation of blood cells, involves the hierarchical differentiation of immature blast cells into mature, functional cell types and lineages of the immune system. Hematopoietic stem cells precisely regulate self-renewal versus differentiation to balance the production of blood cells and maintenance of the stem cell pool. The canonical view of acute myeloid leukemia (AML) is that it results from...

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PMID: 31754026
DOI: 10.1073/pnas.1904091116

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