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Article

Revisiting the differentiation paradigm in acute promyelocytic leukemia

28 Mar 2011

Abstract excerpt

As the result of intense clinical and basic research, acute promyelocytic leukemia (APL) has progressively evolved from a deadly to a curable disease. Historically, efforts aimed at understanding the molecular bases for therapy response have repeatedly illuminated APL pathogenesis. The classic model attributes this therapeutic success to the transcriptional reactivation elicited by retinoic acid and the resulting...

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PMID: 21444912
DOI: 10.1182/blood-2011-02-329367

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