Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare functional variants in genome-wide association identified candidate genes for nonsyndromic clefts in the African population.

American journal of medical genetics. Part A - 1 Oct 2014

Butali Azeez, Mossey Peter, Adeyemo Wasiu, Eshete Mekonen, Gaines Lauren, Braimah Ramat, Aregbesola Babatunde, Rigdon Jennifer, Emeka Christian, Olutayo James, Ogunlewe Olugbenga, Ladeinde Akinola, Abate Fikre, Hailu Taye, Mohammed Ibrahim, Gravem Paul, Deribew Milliard, Gesses Mulualem, Adeyemo Adebowale, Marazita Mary, Murray Jeffrey

Abstract excerpt

Nonsyndromic clefts of the lip and palate (NSCLP) are complex genetic traits. Together, they are classified as one of the most common birth defects with a prevalence of 1/700 live births. Genome-wide association studies (GWAS) for nonsyndromic cleft lip with or without cleft palate (NSCL[P]) revealed significant association for common single nucleotide polymorphisms near genes involved in craniofacial development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cleft Lip

Share to Cleft Palate

Share to Genome-Wide Association Study

Share to GTPase-Activating Proteins

Share to MafB Transcription Factor

Share to PAX7 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 25081408
DOI: 10.1002/ajmg.a.36691
PMCID: PMC4169286

Genes

PAX7
ARHGAP29
MAFB
VAX1
ABCA4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare functional variants in genome-wide association identified candidate genes for nonsyndromic clefts in the African population.PMID 25081408Read ↗

Association Studies and Direct DNA Sequencing Implicate Genetic Susceptibility Loci in the Etiology of Nonsyndromic Orofacial Clefts in Sub-Saharan African Populations.Semantic proximity Read ↗

Rare variants analyses suggest novel cleft genes in the African population.Semantic proximity Read ↗

Rare Variants Analyses Suggest Novel Cleft Genes in the African PopulationSemantic proximity Read ↗

Analysis of genomewide association signals for nonsyndromic cleft lip/palate in a Kenya African Cohort.Semantic proximity Read ↗

Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a Brazilian population with high African ancestry.Semantic proximity Read ↗

Clinically actionable secondary findings in 130 triads from sub-Saharan African families with non-syndromic orofacial clefts.Semantic proximity Read ↗

Different roles of two novel susceptibility loci for nonsyndromic orofacial clefts in a Chinese Han population.Semantic proximity Read ↗

Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.Semantic proximity Read ↗

Novel Protein-Altering Variants in Cleft Genes Transmitted in Families With NSCL±P.Semantic proximity Read ↗

Analysis of sequence data to identify potential risk variants for oral clefts in multiplex familiesSemantic proximity Read ↗

Genomic analyses in African populations identify novel risk loci for cleft palateSemantic proximity Read ↗

The prevalence, penetrance, and expressivity of etiologic IRF 6variants in orofacial clefts patients from sub‐Saharan AfricaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.