Article
Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.
Journal of dental research - 1 Apr 2022
Awotoye W, Comnick C, Pendleton C, Zeng E, Alade A, Mossey P A, Gowans L J J, Eshete M A, Adeyemo W L, Naicker T, Adeleke C, Busch T, Li M, Petrin A, Olotu J, Hassan M, Pape J, Miller S E, Donkor P, Anand D, Lachke S A, Marazita M L, Adeyemo A A, Murray J C, Albokhari D, Sobreira N, Butali A
Abstract excerpt
Risk loci identified through genome-wide association studies have explained about 25% of the phenotypic variations in nonsyndromic orofacial clefts (nsOFCs) on the liability scale. Despite the notable sex differences in the incidences of the different cleft types, investigation of loci for sex-specific effects has been understudied. To explore the sex-specific effects in genetic etiology of nsOFCs, we conducted a...
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