Article

Rare Variants Analyses Suggest Novel Cleft Genes in the African Population

2024-02-27

Abstract excerpt

<title>Abstract</title> <p>Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain only a small proportion of the heritability for NSOFC. Rare variants have been implicated in the missing heritability. Thus, our study aimed to identify genes enriched with nonsynonymous rare coding variants associated with NSOFCs. O...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5550d0c9-9455-5afd-bf0e-7ed7548d9a9d
DOI: 10.21203/rs.3.rs-3921355/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rare Variants Analyses Suggest Novel Cleft Genes in the African PopulationDOI 10.21203/rs.3.rs-3921355/v1Read

Rare variants analyses suggest novel cleft genes in the African population.Semantic proximity Read

Association Studies and Direct DNA Sequencing Implicate Genetic Susceptibility Loci in the Etiology of Nonsyndromic Orofacial Clefts in Sub-Saharan African Populations.Semantic proximity Read

Accumulation of Rare Coding Variants in Genes Implicated in Risk of Human Cleft Lip with or without Cleft PalateSemantic proximity Read

Rare functional variants in genome-wide association identified candidate genes for nonsyndromic clefts in the African population.Semantic proximity Read

Rare variants found in clinical gene panels illuminate the genetic and allelic architecture of orofacial cleftingSemantic proximity Read

Shared genetic risk between major orofacial cleft phenotypes in an African population.Semantic proximity Read

Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.Semantic proximity Read

Distinguishing syndromic and nonsyndromic cleft palate through analysis of protein-altering de novo variants in 816 triosSemantic proximity Read

Assessment of candidate genes and genetic heterogeneity in human non syndromic orofacial clefts specifically non syndromic cleft lip with or without palateSemantic proximity Read

Identification of novel susceptibility genes for non-syndromic cleft lip with or without cleft palate using NGS-based multigene panel testing.Semantic proximity Read

Genomic analyses in African populations identify novel risk loci for cleft palateSemantic proximity Read

Different roles of two novel susceptibility loci for nonsyndromic orofacial clefts in a Chinese Han population.Semantic proximity Read