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Analysis of sequence data to identify potential risk variants for oral clefts in multiplex families

9 Aug 2017

Abstract excerpt

Background Nonsyndromic oral clefts are craniofacial malformations, which include cleft lip with or without cleft palate. The etiology for oral clefts is complex with both genetic and environmental factors contributing to risk. Previous genome-wide association (GWAS) studies have identified multiple loci with small effects; however, many causal variants remain elusive. Methods In this study, we address this by...

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PMID: 28944239
DOI: 10.1002/mgg3.320

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