Article
Association Studies and Direct DNA Sequencing Implicate Genetic Susceptibility Loci in the Etiology of Nonsyndromic Orofacial Clefts in Sub-Saharan African Populations.
Journal of dental research - 1 Oct 2016
Gowans L J J, Adeyemo W L, Eshete M, Mossey P A, Busch T, Aregbesola B, Donkor P, Arthur F K N, Bello S A, Martinez A, Li M, Augustine-Akpan E A, Deressa W, Twumasi P, Olutayo J, Deribew M, Agbenorku P, Oti A A, Braimah R, Plange-Rhule G, Gesses M, Obiri-Yeboah S, Oseni G O, Olaitan P B, Abdur-Rahman L, Abate F, Hailu T, Gravem P, Ogunlewe M O, Buxó C J, Marazita M L, Adeyemo A A, Murray J C, Butali A
Abstract excerpt
Orofacial clefts (OFCs) are congenital dysmorphologies of the human face and oral cavity, with a global incidence of 1 per 700 live births. These anomalies exhibit a multifactorial pattern of inheritance, with genetic and environmental factors both playing crucial roles. Many loci have been implicated in the etiology of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in populations of Asian and...
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