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Article

Genomic analyses in African populations identify novel risk loci for cleft palate

16 Nov 2018

Abstract excerpt

Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with ~17 million markers in sub-Saharan Africans. After replication and combined analyses, we identified novel loci for CPO at or near genome-wide significance on chromosomes...

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PMID: 30452639
DOI: 10.1093/hmg/ddy402

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