Article
Analysis of genomewide association signals for nonsyndromic cleft lip/palate in a Kenya African Cohort.
American journal of medical genetics. Part A - 1 Oct 2011
Weatherley-White R Christopher, Ben Songtao, Jin Ying, Riccardi Sheri, Arnold Thomas D, Spritz Richard A
Abstract excerpt
Nonsyndromic cleft lip with or without cleft palate is a common birth defect with a wide range of prevalence among different populations, apparently highest in Asians and Amerindians and lowest in Africans. Recent genomewide association studies of European-derived and Asian populations have identified six confirmed loci for this phenotype: 1p22.1, 1q32.2 (IRF6), 8q24, 10q25.3, 17q22, and 20q12. However, there...
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