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Article

The chromosomal instability pathway in colon cancer.

Gastroenterology - 1 Jun 2010

Pino Maria S, Chung Daniel C

Abstract excerpt

The acquisition of genomic instability is a crucial feature in tumor development and there are at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability (CIN), microsatellite instability, and CpG island methylator phenotype pathways. Most cases of colorectal cancer arise through the CIN pathway, which is characterized by widespread imbalances in chromosome number (aneuploidy) and...

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Source

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Identifiers

PMID: 20420946
DOI: 10.1053/j.gastro.2009.12.065
PMCID: PMC4243705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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