The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice

Abstract excerpt

The multidrug resistance 2 knockout (Mdr2 –/–) mouse is a well‐established model of cholestatic cholangiopathies. Female Mdr2 –/– mice develop more severe hepatobiliary damage than male Mdr2 –/– mice, which is correlated with a higher proportion of taurocholate in the bile. Although estrogen has been identified as an important player in intrahepatic cholestasis, the underlying molecular mechanisms of gender‐based...

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