Article
Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19.
ACS chemical biology - 17 Oct 2014
Elshahawi Sherif I, Ramelot Theresa A, Seetharaman Jayaraman, Chen Jing, Singh Shanteri, Yang Yunhuang, Pederson Kari, Kharel Madan K, Xiao Rong, Lew Scott, Yennamalli Ragothaman M, Miller Mitchell D, Wang Fengbin, Tong Liang, Montelione Gaetano T, Kennedy Michael A, Bingman Craig A, Zhu Haining, Phillips George N, Thorson Jon S
Abstract excerpt
Calicheamicin γ1I (1) is an enediyne antitumor compound produced by Micromonospora echinospora spp. calichensis, and its biosynthetic gene cluster has been previously reported. Despite extensive analysis and biochemical study, several genes in the biosynthetic gene cluster of 1 remain functionally unassigned. Using a structural genomics approach and biochemical characterization, two proteins encoded by genes from...
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