Resistance gene–guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases

Abstract excerpt

With the significant increase in the availability of microbial genome sequences in recent years, resistance gene–guided genome mining has emerged as a powerful approach for identifying natural products with specific bioactivities. Here, we present the use of this approach to reveal the roseopurpurins as potent inhibitors of cyclin-dependent kinases (CDKs), a class of cell cycle regulators implicated in multiple...

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