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Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases

27 Jul 2018

Abstract excerpt

Enfumafungin is a glycosylated fernene-type triterpenoid produced by the fungus Hormonema carpetanum. Its potent antifungal activity, mediated by its interaction with β-1,3-glucan synthase and the fungal cell wall, has led to its development into the semi-synthetic clinical candidate, ibrexafungerp (=SCY-078). We report on the preliminary identification of the enfumafungin biosynthetic gene cluster (BGC) based on...

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PMID: 30051576
DOI: 10.1111/1462-2920.14333

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