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Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882.

Applied and environmental microbiology - 15 Jun 2018

Wu Hao, Liang Jingdan, Wang Jialiang, Liang Wei-Jun, Gou Lixia, Wu Qiulin, Zhou Xiufen, Bruce Ian J, Deng Zixin, Wang Zhijun

Abstract excerpt

Calcimycin, N-demethyl calcimycin, and cezomycin are polyether divalent cation ionophore secondary metabolites produced by Streptomyces chartreusis A thorough understanding of the organization of their encoding genes, biosynthetic pathway(s), and cation specificities is vitally important for their efficient future production and therapeutic use. So far, this has been lacking, as has information concerning any...

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PMID: 29654174
DOI: 10.1128/AEM.00586-18
PMCID: PMC5981064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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