Article
Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation.
Science (New York, N.Y.) - 5 Feb 2016
Petrou Vasileios I, Herrera Carmen M, Schultz Kathryn M, Clarke Oliver B, Vendome Jérémie, Tomasek David, Banerjee Surajit, Rajashankar Kanagalaghatta R, Belcher Dufrisne Meagan, Kloss Brian, Kloppmann Edda, Rost Burkhard, Klug Candice S, Trent M Stephen, Shapiro Lawrence, Mancia Filippo
Abstract excerpt
Polymyxins are antibiotics used in the last line of defense to combat multidrug-resistant infections by Gram-negative bacteria. Polymyxin resistance arises through charge modification of the bacterial outer membrane with the attachment of the cationic sugar 4-amino-4-deoxy-l-arabinose to lipid A, a reaction catalyzed by the integral membrane lipid-to-lipid glycosyltransferase 4-amino-4-deoxy-L-arabinose...
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