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Article

Evolution of Chemical Diversity in Echinocandin Lipopeptide Antifungal Metabolites

30 May 2015

Abstract excerpt

The echinocandins are a class of antifungal drugs that includes caspofungin, micafungin, and anidulafungin. Gene clusters encoding most of the structural complexity of the echinocandins provided a framework for hypotheses about the evolutionary history and chemical logic of echinocandin biosynthesis. Gene orthologs among echinocandin-producing fungi were identified. Pathway genes, including the nonribosomal...

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PMID: 26024901
DOI: 10.1128/ec.00076-15

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