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Article

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.

Blood - 10 Jun 2010

Shao Lijian, Sun Yan, Zhang Zhonghui, Feng Wei, Gao Yongxing, Cai Zailong, Wang Zack Z, Look A Thomas, Wu Wen-Shu

Abstract excerpt

Bone marrow injury is a major adverse side effect of radiation and chemotherapy. Attempts to limit such damage are warranted, but their success requires a better understanding of how radiation and anticancer drugs harm the bone marrow. Here, we report one pivotal role of the BH3-only protein Puma in the radiosensitivity of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). Puma deficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Radiation

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Share to Tumor Suppressor Protein p53

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Source

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Identifiers

PMID: 20360471
DOI: 10.1182/blood-2009-10-248872
PMCID: PMC2890171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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